A Different Approach To Adeno-Associated-Virus (AAV) Clarification

Combining depth filters with membrane filters offers a cost-effective and easily scalable solution to AAV harvest clarification, contrasting with the expensive upfront investment and scalability challenges of centrifugation. The wide array of chemistries and pore sizes of depth filters enable the customization of production processes for virtually any AAV process.

However, the range of options poses a challenge in determining the optimal combination of depth and membrane/sterile filters. Identifying the best combination through a thorough understanding of the feed stream and process constraints is a practical starting point. With knowledge of the feed stream, process constraints, and goals, selecting depth and membrane filter combinations for preliminary bench-scale filterability investigations becomes feasible.