Vial Filling & Lyophilization
The automated vial-filling line at Cook Pharmica has an annual capacity of 15 million vials and is fully enclosed in a barrier isolator, ensuring an aseptic filling environment. The line is flexible, accommodating either time-pressure filling or filling by peristaltic pump.
Vial Filling, Capping and Lyophilization Under Barrier Isolation
The automated vial-filling line at Cook Pharmica has an annual capacity of 15 million vials and is fully enclosed in a barrier isolator, ensuring an aseptic filling environment. The line is flexible, accommodating either time-pressure filling or filling by peristaltic pump. For products that require lyophilization, there is a 250 sq ft lyophilizer integrated into the vial line within the barrier isolator. This setup allows for automated vial loading and unloading, and for the establishment of a simple and practical process. The product and component pass-throughs and unidirectional flow further reinforce Current Good Manufacturing Practices (CGMP) and processes.
Quick Capability Reference
| Product Types | Large molecule, small molecule, vaccines |
| Vial Sizes | 2-20 mL |
| Filling Speed | 50-150 vials per minute, depending on vial size |
| Annual Capacity | 15 million units |
| Lyophilization Capacity | 250 sq ft |
| Manufacturing Scale | Commercial and clinical |
| Other Features | Automated lyophilizer loading and unloading, capper under barrier isolator, cool zone sterilization (tunnel), integrated material transfer chamber, recirculation capabilities for suspensions, 100% nondestructive weight control |